outlet where to buy cheap real authentic TED Baker Mens DUUKE Trainers Dark Tan sale lowest price discount recommend shop offer sale online bey9MMNQWv

B072Q3PN6L
outlet where to buy cheap real authentic TED Baker Mens DUUKE Trainers Dark Tan sale lowest price discount recommend shop offer sale online bey9MMNQWv
  • Product colour: Brown
  • Material Type: Leather
  • Outer Material: Leather
  • Closure: lace-up
  • Heel Type: low-heel
  • Lining: Leather
  • Insole: Non-Removable
  • Product type: Lace Up
outlet where to buy cheap real authentic TED Baker Mens DUUKE Trainers Dark Tan sale lowest price discount recommend shop offer sale online bey9MMNQWv outlet where to buy cheap real authentic TED Baker Mens DUUKE Trainers Dark Tan sale lowest price discount recommend shop offer sale online bey9MMNQWv outlet where to buy cheap real authentic TED Baker Mens DUUKE Trainers Dark Tan sale lowest price discount recommend shop offer sale online bey9MMNQWv outlet where to buy cheap real authentic TED Baker Mens DUUKE Trainers Dark Tan sale lowest price discount recommend shop offer sale online bey9MMNQWv outlet where to buy cheap real authentic TED Baker Mens DUUKE Trainers Dark Tan sale lowest price discount recommend shop offer sale online bey9MMNQWv

Download citation file:

© 2018 Oxford University Press

Permissions
Close
Advanced Search

Abstract

Background . Although gatifloxacin is no longer available, other fluoroquinolones may significantly interfere with glucose homeostasis. The objective of the present study was to compare the risk of severe hypo- and hyperglycemia in a cohort of patients treated with gatifloxacin, levofloxacin, ciprofloxacin, or azithromycin.

Background

Methods . This was a retrospective inception cohort study of outpatients with a new prescription for gatifloxacin, levofloxacin, ciprofloxacin, or azithromycin from 1 October 2000 through 30 September 2005 in the Veterans Affairs health care system. For patients who received one of these antibiotics, we identified outcomes of hospitalization with a primary diagnosis of hypo- or hyperglycemia. Multivariable logistic regression was used to determine the odds of hypo- and hyperglycemia with the individual fluoroquinolones versus azithromycin.

Methods

Results . The crude incidence rates for severe hypo- and hyperglycemia among those who received gatifloxacin, levofloxacin, ciprofloxacin, and azithromycin were 0.35 and 0.45, 0.19 and 0.18, 0.10 and 0.12, and 0.07 and 0.10 cases per 1000 patients, respectively. Among patients with diabetes, the odds ratios for hypoglycemia compared with azithromycin were 4.3 (95% confidence interval [CI], 2.7–6.6) for gatifloxacin, 2.1 (95% CI, 1.4–3.3) for levofloxacin, and 1.1 (95% CI, 0.6–2.0) for ciprofloxacin. The odds ratios for hyperglycemia were 4.5 (95% CI, 3.0–6.9) for gatifloxacin, 1.8 (95% CI, 1.2–2.7) for levofloxacin, and 1.0 (95% CI, 0.6–1.8) for ciprofloxacin.

Results

Conclusions . The odds of severe hypo- and hyperglycemia were significantly greater with gatifloxacin and levofloxacin, but not ciprofloxacin, than with azithromycin. Thus, the risk of a clinically relevant dysglycemic event appears to vary among the fluoroquinolones.

Conclusions
Topic:
Issue Section:

The fluoroquinolone antibiotics are widely used because they are generally well tolerated and have a broad spectrum of activity. However, gatifloxacin—which had been used in the treatment of a variety of infections, including those involving the skin and the respiratory and genitourinary tracts [ 1 , 2 ]—was withdrawn from the market because of concerns about severe glucose disturbances. Although hypoglycemia and hyperglycemia were reported only rarely during clinical trials with gatifloxacin, severe dysglycemic events, typically in elderly patients and in patients with diabetes, were reported during the postmarketing period [ 3 ] and published in the medical literature [ 4–21 ].

Mobile Menu

Pleaser Women’s Sexy1006 Boot Blk 95 Schwarz Schwarz Blk Pat footlocker finishline for sale shipping discount sale sale lowest price cheap sale footaction GOF6X

Arctic Council

A high level intergovernmental forum to provide a means for promoting cooperation, coordination and interaction among the Arctic States, with the involvement of the Arctic Indigenous communities and other Arctic inhabitants...

Read More

Members

The Arctic Council is made up of eight Member States, six indigenous Permanent Participant organizations, six Working Groups, three Task Forces, one Expert Group, and 32 observers…

Learn More

Working Groups

Many of the Arctic Council's activities are conducted in six working groups. Their work covers a broad field of subjects, from climate change to emergency response...

Wrangler WM181081 Low Sneakers Man Blue sale pictures smd4wL

Task Forces

The Arctic Council currently has two active Task Forces working on different issues, such as the Arctic marine environment and telecommunications...

Learn More

Black Carbon EG

Arctic States and observers are acting together to reduce emissions of black carbon and methane with the ambition to slow Arctic warming in the near to medium term...

Learn More

Events

Senior Arctic Officials meet twice a year and Arctic Ministers meet every other year. Visit our calendar for a list of upcoming events...

outlet 100% original sale 2014 newest Be Natural Women’s 28205 Wedge Heels Sandals Pink Rose 521 cheap fashion Style bw49Y2M2Z

Archive

Visit the Arctic Council Open Access Archive for documents such as scientific assessments and reports about the Arctic...

Donald J Pliner Womens Chea Stone cheap sale many kinds of pay with paypal sale online best store to get cheap online countdown package sale online sale sneakernews NVmBlEU

Finnish Chairmanship

Learn more about the 2017-2019 Finnish Chairmanship of the Arctic Council.

Fairbanks Declaration

Read the Arctic Council’s guiding document for 2017-2019, signed at the 10th Ministerial meeting

Working Groups

buy online cheap price Munich Unisex Adults Goal Trainers Several Colours 1379 1379 Navy Blue low price for sale cheap sale best seller best wholesale sale online SMfen

Media Resources

Visit the Press Room for press releases, photos, contact information, and other resources.

In The News
04 July 2018 15:44

The Arctic Council is proud to host a Ministerial side event at the UN High-level Political Forum on Sustainable Development 2018, taking place in New York.

Zamberlan

CALZATURIFICIO ZAMBERLAN SRL

Via Marconi, 1

Pieve di Torrebelvicino

36036 VI

P.IVA: 01274380243

Discover Zamberlan
Information

Sign Up for Our Newsletter

Stay in touch wuth us!

Copyright © 2018 Zamberlan. All rights reserved. adidas Unisex Adults Samba LowTop Sneakers White Blue Azufue/Naranj/Gum5 000 low shipping fee online sale affordable outlet get authentic best prices cheap price with mastercard for sale qg7Ut
User agreement Cookies policy - Powered by Sanita Women’s Jessy Open Clogs Green Green Green 25 cheapest price sale geniue stockist outlet low cost Bdu5O7